Journal
EXPERIMENTAL CELL RESEARCH
Volume 312, Issue 16, Pages 3108-3119Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2006.06.017
Keywords
HCNR; CNS; development; transcriptional code; Sox; POU; homeodomain; transcription factor
Categories
Funding
- Medical Research Council [MC_U137761446] Funding Source: Medline
- Medical Research Council [MC_U137761446] Funding Source: researchfish
- MRC [MC_U137761446] Funding Source: UKRI
Ask authors/readers for more resources
Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression. (c) 2006 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available