Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 100, Issue 10, Pages 1679-1684Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2006.05.018
Keywords
selenoprotein W; mouse development; myoblast differentiation; oxidative stress
Funding
- NIDDK NIH HHS [DK54226] Funding Source: Medline
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Selenium is involved in prevention of cancer, heart and muscle diseases, is implicated in immune function, fertility and in delaying the aging process. Selenium deficiency is harmful to brain, heart and skeletal muscles. Selenoprotein W, a member of the selenoprotein family was expressed in developing nervous system, skeletal muscles and heart in mice. Selenoprotein W was highly expressed in proliferating myoblasts and less or not in differentiated myotubes. Selenoprotein W exhibited an immediate response to oxidative stress in proliferating myoblasts, after exposure to hydrogen peroxide, similar to gluteraldehyde-3-phosphate dehydrogenase. We suggest that Selenoprotein W is involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress. (c) 2006 Elsevier Inc. All rights reserved.
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