Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 7, Pages 4662-4669Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.7.4662
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Funding
- NCI NIH HHS [T32 CA 82084-07] Funding Source: Medline
- NIAID NIH HHS [AI 060525, AI 37859, R01 AI 50732] Funding Source: Medline
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IL-17 is a cytokine produced by T cells in response to IL-23. Recent data support a new subset of CD4 Th cells distinct from Th1 or Th2 cells that produce IL-17 and may contribute to inflammation. In this study, we demonstrate that, in naive mice, as well as during Mycobacterium tuberculosis infection, IL-17 production is primarily from gamma delta T cells and other non-CD4(+)CD8(+) cells, rather than CD4 T cells. The production of IL-17 by these cells is stimulated by IL-23 alone, and strongly induced by the cytokines, including IL-23, produced by M. tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as gamma delta T cells, may represent a central innate protective response to pulmonary infection.
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