Preparation and electrocatalytic performance of functionalized copper-based nanoparticles supported on the gold surface

Copper nanoparticles (CuNPs) encapsulated by polymeric stabilizer of polyvinylpyrrolidone (PVP) (noted as PVPCuNPs) were simply prepared and used to construct an enzymeless glucose sensor on a solid substrate. Sensing and assay performance of the CuNPs-based sensor to glucose were evaluated in detail. Cyclic voltammetry (CV), chronoamperometry (I-t) and flow injection amperometry (FIA) revealed a high sensitivity, excellent stability, and good reproducibility in the glucose determination at +0.45 V, which was 200 mV more negative than those in former reports. A detection limit as low as 1.0 x 10(-8) M (signal-to-noise =3) and a linear range of 1.0 x 10(-1) M to 5.0 x 10(-3) M were obtained in this study.