Journal
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Volume 11, Issue 3-4, Pages 213-228Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-006-9027-z
Keywords
Drosophila trachea; air sacs; lung; kidney; submandibular gland; mammary gland; prostate; epithelial-mesenchymal crosstalk
Categories
Funding
- NCI NIH HHS [CA057621, R01 CA057621, CA058207, R01 CA057621-15, P50 CA058207, P50 CA058207-14] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007731-17, T32 HL007731, HL07731] Funding Source: Medline
- NIEHS NIH HHS [U01 ES012801-04S3, ES012801, U01 ES012801] Funding Source: Medline
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Much progress has been made in recent years toward understanding mechanisms controlling branching morphogenesis, a fundamental aspect of development in a variety of invertebrate and vertebrate organs. To gain a deeper understanding of how branching morphogenesis occurs in the mammary gland, we compare and contrast the cellular and molecular events underlying this process in both invertebrate and vertebrate organs. Thus, in this review, we focus on the common themes that have emerged from such comparative analyses and discuss how they are implemented via a battery of signaling pathways to ensure proper branching morphogenesis in diverse systems.
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