4.8 Article

Polymer microarrays: Identification of substrates for phagocytosis assays

Journal

BIOMATERIALS
Volume 27, Issue 30, Pages 5299-5306

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2006.04.040

Keywords

dendritic cells; microarrays; polyurethane; cell adhesion; phagocytosis

Funding

  1. Biotechnology and Biological Sciences Research Council [E18330/2] Funding Source: researchfish
  2. Engineering and Physical Sciences Research Council [EP/C54157X/1] Funding Source: researchfish
  3. Biotechnology and Biological Sciences Research Council [E18330/2] Funding Source: Medline
  4. Cancer Research UK [10601] Funding Source: Medline
  5. Wellcome Trust Funding Source: Medline

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A polymer microarray of 120 polyurethanes was used to identify polymers that promoted the adhesion of bone marrow dendritic cells (BMDC). Identified polymers were coated onto glass cover slips and shown to be efficient substrates for the immobilisation of these primary cells, which underwent efficient phagocytosis while still presumably maintaining their immature state. (c) 2006 Elsevier Ltd. All rights reserved.

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