Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 17, Issue 5, Pages 565-570Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2006.09.003
Keywords
review; gabapentin; pregabalin; neurontin; lyrica; voltage gated calcium channel; review; pain
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Gabapentin is a drug that has been widely used in the treatment of chronic pain states. Despite its widespread usage, it is only recently that light has been shed on the mechanism of action of this agent. In the current review, the authors document the pharmacological, biochemical and molecular information that has led to the identification of the alpha 2 delta 1 auxilliary subunit of voltage gated calcium channels as the target for this drug's actions. (c) 2006 Elsevier Ltd. All rights reserved.
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