Journal
NEUROCHEMICAL RESEARCH
Volume 31, Issue 10, Pages 1181-1190Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-006-9143-6
Keywords
glutamate receptors; GluR3; autoantibodies; epilepsy; whole cell recording; oocytes; AMPA receptor; brain
Categories
Ask authors/readers for more resources
Autoantibodies to the GluR3-subtype of AMPA/glutamate receptors are found in the sera and cerebrospinal fluid of some individuals with epilepsy. They could possibly play a role in the pathophysiology of epilepsy since anti-GluR3 sera display glutamatergic agonist activity. We have investigated here the ability of affinity-purified antibodies (Abs) directed against the immunogenic peptide GluR3B (amino-acid 372-395) to interact with and activate recombinant GluR3-receptor channels expressed by Xenopus oocytes. We report here that the affinity-purified anti-GluR3B Abs directly activate GluR3-containing homomeric and heteromeric AMPA receptor complexes without the requirement of neuronal, glial or blood ancillary molecules. We present some of the properties of the purified anti-GluR3B Abs and discuss the possible physiological or pathological consequences of their activation of glutamate receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available