Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 6, Issue 5, Pages 509-514Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2006.04.004
Keywords
-
Categories
Ask authors/readers for more resources
High molecular weight biomolecules are becoming more and more important in the development of new therapeutic drugs. However, the hydrophilic nature of such molecules creates a major limitation for their application - poor penetration through biological membranes. In 1994, a new class of peptides - ceil-penetrating peptides (CPPs) - was discovered. CPPs seem to greatly facilitate the delivery of hydrophilic macromolecules over the plasma membrane, both in vitro and in vivo, and show promise for therapeutic purposes. One such example - suppressor of cytokine signalling 3 protein - was shown to act as an effective inhibitor of acute inflammation in vivo owing to its successful delivery by CPPs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available