Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 39, Issue 4, Pages 1235-1251Publisher
SPRINGER
DOI: 10.1007/s10439-011-0280-y
Keywords
Transferrin; Epidermal growth factor; Transforming growth factor-alpha; Folate; Interleukin-13; Targeted delivery
Categories
Funding
- NIH [P50CA097257]
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Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic molecule. However, it has been found that the therapeutic efficacy of such ligand-drug molecular conjugates can be limited, since they naturally follow the intracellular trafficking pathways of the endogenous ligands. Therefore, a thorough understanding of the intracellular trafficking properties of these ligands can lead to novel design criteria for engineering ligands to be more effective drug carriers. This review presents a few commonly used ligand/receptor systems where intracellular trafficking considerations can potentially improve the therapeutic efficacy of the ligand-drug molecular conjugates.
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