Journal
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Volume 62, Issue -, Pages 1208-1217Publisher
BLACKWELL PUBLISHING
DOI: 10.1107/S0907444906029350
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Funding
- MRC [G0400717, G9900061, MC_U137884178] Funding Source: UKRI
- Medical Research Council [G9900061, MC_U137884178, G0400717] Funding Source: researchfish
- Medical Research Council [G9900061, MC_U137884178, G0400717] Funding Source: Medline
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The EC 'Structural Proteomics In Europe' contract is aimed specifically at the atomic resolution structure determination of human protein targets closely linked to health, with a focus on cancer ( kinesins, kinases, proteins from the ubiquitin pathway), neurological development and neurodegenerative diseases and immune recognition. Despite the challenging nature of the analysis of such targets, similar to 170 structures have been determined to date. Here, the impact of high- throughput technologies, such as parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens or the use of mass spectrometry to assist sample preparation, on the structural biology of mammalian protein targets is illustrated through selected examples.
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