Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 21, Issue 10, Pages 1600-1607Publisher
WILEY
DOI: 10.1359/JBMR.060705
Keywords
hypothalamus; cortical bone; Y2 receptor; leptin; bone formation
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NeuropeptideY-, Y2 receptor (Y2)-, and leptin-deficient mice show similar anabolic action in cancellous bone but have not been assessed in cortical bone. Cortical bone mass is elevated in Y2(-/-) mice through greater osteoblast activity. In contrast, leptin deficiency results in reduced bone mass. We show opposing central regulation of cortical bone.
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