Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 38, Issue 3, Pages 1164-1177Publisher
SPRINGER
DOI: 10.1007/s10439-010-9899-3
Keywords
Cell culture; Cancer; Tissue engineering; Liver; Vascular networks
Categories
Funding
- NIBIB NIH HHS [EB003805] Funding Source: Medline
Ask authors/readers for more resources
Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide enormous flexibility in controlling the critical biochemical and biomechanical factors that influence cell behavior, (ii) allow for the introduction of multiple cell types in a single system, (iii) provide for the establishment of biochemical gradients in two- or three-dimensional geometries, and (iv) allow for high quality, time-lapse imaging. Here, some of the recent developments are reviewed, with a focus on studies from our own laboratory in three separate areas: angiogenesis, cell migration in the context of tumor cell-endothelial interactions, and liver tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available