Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 7, Pages 4267-4270Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.7.4267
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Inflammation plays an important role in the onset of angiogenesis. In the present study, we show that osteopontin (OPN), a proinflammatory mediator involved in tissue repair, induces IL-1 beta up-regulation in human monocytes. This was accompanied by the enhanced production of TNF-alpha, IL-8, and IL-6 a decreased release of IL-10, and increased p38 phosphorylation. The supernatants of OPN-treated monocytes were highly angiogenic when delivered on the chick embryo chorioallantoic membrane. The angiogenic response was completely abrogated by a neutralizing anti-IL-1Ab thus indicating that thin cytokine represents the major proangiogenic factor expressed by OPN-activated monocytes. Accordingly, rIL-1 beta mimicked the proangiogenic activity of OPN-treated monocyte supernatants, and IL-1R (type I) was found to be expressed in the chorioallantoic membrane. In conclusion, OPN-activated monocytes may contribute to the onset of angiogenesis through a mechanism mediated by IL-1 beta.
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