Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 36, Issue 4, Pages 604-621Publisher
SPRINGER
DOI: 10.1007/s10439-008-9464-5
Keywords
shear stress; catch bonds; tethering rate; selectins; on-rate; off-rate
Categories
Funding
- NHLBI NIH HHS [R01 HL065631, R01 HL065631-05, HL65631] Funding Source: Medline
- NIAID NIH HHS [R01 AI044902-04, R01 AI044902-08, R01 AI044902-06, R01 AI044902-05, R01 AI044902-02S1, R21 AI044902, R01 AI044902-03, R01 AI044902, R01 AI044902-01A2, R01 AI044902-07, AI44902, R01 AI044902-02, R01 AI044902-09, R21 AI044902-01A1, R01 AI044902-06S1] Funding Source: Medline
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Cell adhesion is mediated by specific receptor-ligand bonds. In several biological systems, increasing flow has been observed to enhance cell adhesion despite the increasing dislodging fluid shear forces. Flow-enhanced cell adhesion includes several aspects: flow augments the initial tethering of flowing cells to a stationary surface, slows the velocity and increases the regularity of rolling cells, and increases the number of rollingly adherent cells. Mechanisms for this intriguing phenomenon may include transport-dependent acceleration of bond formation and force-dependent deceleration of bond dissociation. The former includes three distinct transport modes: sliding of cell bottom on the surface, Brownian motion of the cell, and rotational diffusion of the interacting molecules. The latter involves a recently demonstrated counterintuitive behavior called catch bonds where force prolongs rather than shortens the lifetimes of receptor-ligand bonds. In this article, we summarize our recently published data that used dimensional analysis and mutational analysis to elucidate the above mechanisms for flow-enhanced leukocyte adhesion mediated by L-selectin-ligand interactions.
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