Journal
ANNALS OF APPLIED STATISTICS
Volume 6, Issue 2, Pages 476-496Publisher
INST MATHEMATICAL STATISTICS
DOI: 10.1214/11-AOAS517
Keywords
Copy number; CNV; change point; inhomogeneous Poisson process; point-wise confidence interval
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Funding
- NSF [DMS-10-43204, DMS-09-06394]
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We propose a flexible change-point model for inhomogeneous Poisson Processes, which arise naturally from next-generation DNA sequencing, and derive score and generalized likelihood statistics for shifts in intensity functions. We construct a modified Bayesian information criterion (mBIC) to guide model selection, and point-wise approximate Bayesian confidence intervals for assessing the confidence in the segmentation. The model is applied to DNA Copy Number profiling with sequencing data and evaluated on simulated spike-in and real data sets.
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