Journal
SCHIZOPHRENIA BULLETIN
Volume 32, Issue 4, Pages 692-700Publisher
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbj050
Keywords
schizophrenia; sensory gating; neuropsychological tests; symptoms; antipsychotics
Categories
Funding
- NIMH NIH HHS [P30 MH068580] Funding Source: Medline
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A large percentage of patients with schizophrenia are characterized by an abnormality in P50 sensory gating. This abnormality has been shown to be genetically linked to the alpha-7 nicotinic receptor and is transiently reversed by acute nicotine administration. These observations have led to the development of pharmacological treatments designed to improve sensory gating. However, if normalization of P50 gating abnormalities is to guide drug development, then it becomes important to delineate the clinical correlates of enhanced P50 gating. We conducted a review of all available articles through March 2005 that have examined this issue. We found that, despite the prominent role that P50 abnormalities have played in our understanding of schizophrenia, there is a relative dearth of data examining P50 clinical correlates. There is evidence suggestive of an association between P50 and measures of attention, and multiple studies have failed to document a cross-sectional or longitudinal relationship between P50 and positive, negative, or other symptoms. These results suggest that considerably more work needs to be done to understand and validate the clinical significance of this impairment.
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