Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 6, Issue 10, Pages 1169-1177Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955706778560120
Keywords
organosilicon chemistry; silicon switch; marketed drugs; validated targets
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The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.
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