Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 6, Issue 10, Pages 1127-1136Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955706778560139
Keywords
kinases; Akt; PI3K; cancer; kinase inhibitors; allosteric inhibitors; phosphatidylinositol; phosphatidylinositol analogues
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Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.
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