Journal
PEDIATRIC DIABETES
Volume 7, Issue 5, Pages 274-278Publisher
WILEY
DOI: 10.1111/j.1399-5448.2006.00202.x
Keywords
case; control study; HLA; LYP; PTPN22 gene; type 1 diabetes
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Funding
- NICHD NIH HHS [1R21HD050196, 2R01HD37800] Funding Source: Medline
- NIDDK NIH HHS [DK-32493, DK-32083, P30DK 57516, 1R21DK069878] Funding Source: Medline
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Objectives: The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado. Subjects and methods: The C1858T single-nucleotide polymorphism within the PTPN22 gene was genotyped in 753 patients with T1D ascertained from the diabetes clinic at the Barbara Davis Center in Denver and 662 control population. Results: Both the PTPN22 CT genotype [odds ratio (OR) = 1.96; p < 0.0001] and TT genotype (OR = 4.41; p = 0.02) were significantly associated with T1D in the NHW population. While the association was stronger in subjects with non-HLA-DR3/4 genotypes than in those with the HLA-DR3/4 genotype, regression analyses did not reveal significant interaction between PTPN22 genotypes and HLA-DR3/4. The strength of the association was similar in males and females, patients diagnosed before and after age 10 yr, and in Hispanics and NHWs. Conclusion: In this study, we confirm that PTPN22 is associated with T1D in the Colorado population.
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