Journal
NATURE BIOTECHNOLOGY
Volume 24, Issue 10, Pages 1253-1254Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1249
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Funding
- NCRR NIH HHS [U54RR020839-01] Funding Source: Medline
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The most challenging step in protein microarray fabrication is high-throughput production of proteins. Here we report two similar strategies to fabricate protein chips through capture onto a solid surface of the nascent polypeptides during translation of synthetic or in vitro-transcribed RNAs. Using these approaches, we efficiently fabricated both peptide and protein microarrays at relatively high density. We further demonstrated that such protein chips can be used to analyze protein activity.
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