Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 142, Issue 4, Pages 425-427Publisher
SPRINGER
DOI: 10.1007/s10517-006-0383-x
Keywords
N-docosahexaenoyl dopamine; N-acyldopamines; antioxidants; neuroprotection; Parkinson's disease
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N-Docosahexaenoyl dopamine exhibited antioxidant activity in the test with a stable oxygen radical galvinoxyl. This compound produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. N-Docosahexaenoyl dopamine decelerated the development of symptoms of Parkinson's disease in mice receiving neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
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