Journal
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
Volume 191, Issue 6, Pages 518-531Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.aanat.2009.08.006
Keywords
Hippocampus; Dendritic spines; Neuronal plasticity; Learning; Memory; Mental retardation; Depression
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Most excitatory input in the hippocampus impinges on dendritic spines. Therefore, the dendritic spines are likely to be of major importance for neural processing. The morphology of dendritic spines is very diverse and changes in spine size as well as in their density are thought to reflect changes in the strength of synaptic transmission. Thus, alterations in dendritic spine densities or shape are suspected to be morphological manifestations of psychopathological, pathophysiological, physiological and/or behavioural changes. However, in spite of a tong history of research, the specific function of dendritic spines within the hippocampal formation is still not welt understood. This review will shed light on the hippocampal dendritic spines, their ultrastructure and morphology, as well as their supposed rotes in neuronal plasticity and in certain mental illnesses. (C) 2009 Elsevier GmbH. All. rights reserved.
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