Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 36, Issue 12, Pages 1241-1244Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2006.07.002
Keywords
Schistosoma; baboon; vaccine; chemotherapy; circulating antigens; faecal eggs
Categories
Ask authors/readers for more resources
In human schistosomiasis mansoni, it is impossible to directly determine worm burden and hence infection intensity, so surrogates must be used. Studies on non-human primates revealed a linear relationship between worm burden and three surrogates, faecal egg output, circulating anodic and circulating cathodic antigens. By regression, the thresholds of detection were determined as 40, 24 and 47 worms, respectively. These observations provide a quantitative basis for the contention that low intensity infections in humans are being missed. The significance for estimates of disease prevalence, evaluation of the effects of chemotherapy and the implementation of vaccine trials is emphasised. (c) 2006 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available