Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 10, Pages 775-782Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2005
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Recently, a method to encode unnatural amino acids with diverse physicochemical and biological properties genetically in bacteria, yeast and mammalian cells was developed. Over 30 unnatural amino acids have been co-translationally incorporated into proteins with high fidelity and efficiency using a unique codon and corresponding transfer-RNA: aminoacyl-tRNA-synthetase pair. This provides a powerful tool for exploring protein structure and function in vitro and in vivo, and for generating proteins with new or enhanced properties.
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