Journal
BEHAVIORAL NEUROSCIENCE
Volume 120, Issue 5, Pages 1159-1162Publisher
AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION
DOI: 10.1037/0735-7044.120.5.1159
Keywords
D-cycloserine; NMDA; extinction; renewal; conditioned fear
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Funding
- NIMH NIH HHS [R01 MH064847, R01 MH64847] Funding Source: Medline
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The effect Of D-CyCloserine (DCS), an NMDA partial agonist, on extinction of fear was investigated in rats using the conditioned emotional response preparation. Fear extinction was facilitated when the first 4 trials occurred with a 30-mg/kg dose of DCS. However, extinguished fear was renewed regardless of the drug treatment when the rats were returned to the context in which fear had been conditioned. Additional results suggest that DCS's facilitation of extinction is a small but meaningful effect in the current method. The results suggest caution regarding the use of DCS as an adjunct to extinction: Although the drug may modestly facilitate extinction learning, it does not necessarily destroy the potential for relapse. Behavioral mechanisms are discussed.
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