Journal
IMMUNITY
Volume 25, Issue 4, Pages 533-543Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2006.09.005
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- Intramural NIH HHS Funding Source: Medline
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Antiviral CD8(+) T cells respond to only a minute fraction of the potential peptide determinants encoded by viral genomes. Immunogenic determinants can be ordered into highly reproducible hierarchies based on the magnitude of cognate CD8(+) T cell responses. Until recently, this phenomenon, termed immunodominance, was largely defined and characterized in model systems utilizing a few strains of inbred mice infected with a handful of viruses with limited coding capacity. Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity.
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