Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 7, Pages 4426-4435Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.7.4426
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- NCRR NIH HHS [RR 00059] Funding Source: Medline
- NHLBI NIH HHS [HL 007638, HL 073967, HL 077431] Funding Source: Medline
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The mechanisms regulating IL-4 mRNA stability in differentiated T cells are not known. We found that early exposure of CD4(+) T cells to endogenous IL-4 increased IL-4 mRNA stability. This effect of IL-4 was mediated by the RNA-binding protein HuR. IL-4 mRNA interacted with HuR and the dominant binding site was shown within the coding region of IL-4 mRNA. Exposure of CD4(+) T cells to IL-4 had no effects on HuR expression or subcellular localization, but triggered HuR binding to IL-4 mRNA. Thus, IL-4 plays a positive role in maintaining IL-4 mRNA stability in CD4(+) T cells via a HuR-mediated mechanism.
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