Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 173, Issue 1, Pages 112-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2006.06.005
Keywords
Crocus sativus L.; memory; scopolamine; object recognition; passive avoidance; rat
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The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of CSE (30 and 60 g/kg) successfully counteracted extinction of recognition memory in the normal rat, suggesting that CSE modulates storage and/or retrieval of information. In a subsequent study, pre-training treatment with CSE (30 and 60 mg/kg) significantly antagonized the scopolamine (0.75 mg/kg)-induced performance deficits in the step-through passive avoidance test. These results support and extend prior findings about the implication of CSE in learning and memory mechanisms. (c) 2006 Elsevier B.V. All rights reserved.
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