Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 40, Pages 14913-14918Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0602045103
Keywords
aminoacyl-tRNA synthetase; glucagon; pancreas
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AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wildtype mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
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