Journal
FEBS LETTERS
Volume 580, Issue 23, Pages 5492-5499Publisher
WILEY
DOI: 10.1016/j.febslet.2006.07.082
Keywords
cholesterol; farnesoid X receptor; gallstones; hypertriglyceridemia; metabolic syndrome
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The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is primarily expressed in the enterohepatic system where it functions as intracellular sensor for bile acids. Ligand dependent FXR activation induces transcriptional responses to coordinately regulate bile acid, cholesterol, triglyceride and glucose metabolism, and to protect the intestinal mucosa from bacterial overgrowth and inflammatory insults. Here we discuss the latest discoveries in FXR-driven metabolic pathways with relevance to pathophysiology and novel therapeutic approaches of several conditions such as hypertriglyceridemia, type 2 diabetes, cholesterol gallstone disease, steato-hepatitis and metabolic syndrome. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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