Journal
VIROLOGY
Volume 354, Issue 1, Pages 80-90Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.06.024
Keywords
influenza; sialic acid; respiratory epithelial cells; airway epithelium; ciliated cells; clara cells; goblet cell; virus receptors; virus tropism
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Funding
- NIAID NIH HHS [AI053629, R01 AI053629] Funding Source: Medline
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The ability of several different influenza A virus strains to infect and replicate in primary, differentiated airway epithelial cell cultures from Syrian golden hamsters was investigated. All virus strains tested replicated equivalently in the cultures and displayed a preference for infecting nonciliated cells. This tropism correlated with the expression of both alpha 2,3- and alpha 2,6-linked sialic acid on the nonciliated cells. In contrast, the ciliated cells did not have detectable alpha 2,6-linked sialic acid and expressed only low amounts of alpha 2,3-linked sialic acid. In contrast to clinical isolates, laboratory strains of influenza A virus infected a limited number of ciliated cells at late times post-infection. The presence of alpha 2,3- and alpha 2,6-linked sialic acid residues on the same cell type suggests that Syrian golden hamsters and differentiated airway epithelial cell cultures derived from hamsters may provide a system for studying the reassortment of influenza A virus strains which utilize different forms of sialic acid as a primary virus receptor. (c) 2006 Elsevier Inc. All rights reserved.
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