Journal
JOURNAL OF CONTROLLED RELEASE
Volume 115, Issue 2, Pages 130-133Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2006.07.015
Keywords
polyamine; bile acid; intestinal absorption; beagle dog; bile duct ligated rat
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The synergetic improving effect of bile acids with spermine (SPM), a major polyamine, on the absorption of rebamipide, a poorly soluble and poorly absorbable drug (BCS Class IV), was evaluated in rats and beagle dogs. Although the absorption of rebamipide was improved by the addition of polyamines alone in normal rats, it was not improved in bile duct ligated (BDL) rats. The combinatorial use of sodium taurocholate (STC), a bile acid, with SPM improved the absorption of rebamipide even in BDL rats. In the beagle dogs, the oral administration of SPM alone did not enhance the absorption of rebamipide, but the combinatorial use of STC with SPM improved the absorption as well as in the BDL rats. These results indicate that bile acids are indispensable for the novel formulation containing SPM to improve the absorption of rebannipide after oral administration. (c) 2006 Elsevier B.V. All rights reserved.
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