Journal
ANALYTICA CHIMICA ACTA
Volume 579, Issue 2, Pages 202-208Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2006.07.027
Keywords
trace elements; blood; dynamic reaction cell inductively coupled plasma mass spectrometry; desolvating system
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A quadrupole inductively coupled plasma mass spectrometer (Q-ICP-MS) equipped with a dynamic reaction cell (DRC) and coupled with a desolvating nebulization system (APEX-IR) was employed to determine 17 elements (Al, As, Ba, Cd, Co, Cr, U, Mn, Mo, Ni, Pb, Sb, Se, Sn, Sr, V, and Zr) in blood samples. Ammonia (for Al, Cr, Mn, and V) and 02 (for As and Se) were used as reacting gases. Selection of the best flow rate of the gases and optimization of the quadrupole dynamic bandpass tuning parameter (RPq) were carried out, using digested blood diluted 1 + 9 with deionized water and spiked with 1 mu g L-1 of Al, Cr, Mn, V and 5 mu g L-1 of As and Se. Detection limits were determined in digested blood using the 3 sigma criterion. The desolvating system allowed a sufficient sensitivity to be achieved to determine elements at levels of ng L-1 without detriment of signal stability. The accuracy of the method was tested with the whole blood certified reference material (CRM), certified for Al, As, Cd, Co, Cr, Mn, Mo, Ni, Pb, Sb, Se, and V, and with indicative values for Ba, Li, Sn, Sr, and Zr. The addition calibration approach was chosen for analysis. In order to confirm the DRC data, samples were also analyzed by means of sector field inductively coupled plasma mass spectrometry (SF-ICP-MS), operating in medium (m/Delta m = 4000) and high (m/Delta m = 10,000) resolution mode and achieving a good agreement between the two techniques. (c) 2006 Elsevier B.V. All rights reserved.
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