Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 41, Pages 10376-10379Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3379-06.2006
Keywords
basal ganglia; birdsong; brain development; chromatin immunoprecipitation; forkhead; FOXP2; language; motor learning; song; speech; zebra finch
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Funding
- NIDCD NIH HHS [R01 DC005964, R56 DC005964, DC005964] Funding Source: Medline
- NIMH NIH HHS [R01 MH070712, R01 MH070712-02, MH075028, MH070712, R21 MH075028] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis of an inherited speech and language disorder suffered by members of the family known as KE. This mini-symposium review focuses on recent findings and research-in-progress, primarily from five laboratories. Each aims at capitalizing on the FOXP2 discovery to build a neurobiological bridge between molecule and phenotype. Below, we describe genetic through behavioral techniques used currently to investigate FoxP2 in birds, rodents, and humans for discovery of the neural bases of vocal learning and language.
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