Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 21, Pages 8244-8249Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo061406i
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Funding
- NCI NIH HHS [CA02848, CA28824] Funding Source: Medline
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An advance in the long-term problem of joining complex oligosaccharides to polypeptides and even proteins is described herein. The key method involves equipping the oligosaccharide sector with an azide and the polypeptide with pendant alkynyl functionality. The two sectors are joined through a click-like cycloaddition. The method encompasses oligosaccharide constructs with several azide linkages which undergo concurrent cycloaddition to peptide-based acetylenes. This technology could well prove to be useful in the construction of fully synthetic vaccines.
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