4.7 Article

Molecular iodine-catalyzed facile procedure for N-boc protection of amines

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 21, Pages 8283-8286

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo0612473

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An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)(2)O in the presence of a catalytic amount of molecular iodine (10 mol %) under solvent-free conditions at ambient temperature is presented.

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