Journal
NEUROIMAGE
Volume 33, Issue 1, Pages 85-93Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2006.06.016
Keywords
GABA; gray and white matter; human brain in vivo; MRS; CSI
Funding
- Intramural NIH HHS Funding Source: Medline
- NIA NIH HHS [R03AG022193] Funding Source: Medline
- NIBIB NIH HHS [8R01EB00315] Funding Source: Medline
Ask authors/readers for more resources
A novel selective multiple quantum filtering-based chemical shift imaging method was developed for acquiring GABA images in the human brain at 3 T. This method allows a concomitant acquisition of an interleaved total creatine image with the same spatial resolution. Using T-1-based image segmentation and a nonlinear least square regression analysis of GABA-to-total creatine concentration ratios in frontal and parietal lobes of healthy adult volunteers as a function of the tissue gray matter fraction, the mean GABA concentration in gray and white matter was determined to be 1.30 +/- 0.36 mu mol/g and 0.16 +/- 0.16 mu mol/g (mean +/- SD, n=13), respectively. It is expected that this method will become a useful tool for studying GABAergic function in the human brain in vivo. (c) 2006 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available