Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 64, Issue 14, Pages 718-726Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2014.1002129
Keywords
Biocompatible; chemo-resistance; doxorubicin; drug delivery; nanoparticles; polymers; super paramagnetic
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To increase the efficacy of doxorubicin in induction of apoptosis, pH-responsive nanocarriers with an average particle size of 20nm by using chitosan-polymethacrylic acid (CTS-PMAA) shells and Fe3O4 cores via in situ polymerization approach were synthesized. Doxorubicin hydrochloride (DOX) was loaded effectively to nanocarrier through electrostatic interactions and strong hydrogen banding. The cumulative release of DOX-loaded nanoparticles was pH dependent with a maximum release rate at pH 5.8. In vitro cytotoxicity assay revealed the biocompatibility of blank nanocarrier and superior anticancer performance of DOX-loaded nanoparticles verified by DAPI staining and MTT assay tests. [GRAPHICS] .
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