Journal
JOURNAL OF CELL SCIENCE
Volume 119, Issue 20, Pages 4143-4153Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.03226
Keywords
centrosome; gamma-tubulin; microtubule; nucleation; XMAP215; TACC; TPX2; aurora A
Categories
Ask authors/readers for more resources
Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)- organizing centers in eukaryotic cells. Several proteins have been implicated in microtubule formation by centrosomes and SPBs, including microtubule-minus-end-binding proteins and proteins that bind along the length or stabilize the plus ends of microtubules. Recent work has improved our understanding of the molecular mechanisms of MT formation. In particular, it has shown that gamma-tubulin and its associated proteins play key roles in microtubule nucleation and spindle assembly in evolutionarily distant species ranging from fungi to mammals. Other work indicates that gamma-tubulin-mediated microtubule nucleation, although necessary, is not sufficient for mitotic spindle assembly but requires additional proteins that regulate microtubule nucleation independently of centrosomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available