Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 42, Pages 15646-15650Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0607443103
Keywords
gap junction; intrinsic bursting; layer 5; M current; neocortex
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Funding
- Wellcome Trust Funding Source: Medline
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Beta2 frequency (20-30 Hz) oscillations appear over somatosensory and motor cortices in vivo during motor preparation and can be coherent with muscle electrical activity. We describe a beta2 frequency oscillation occurring in vitro in networks of layer V pyramidal cells, the cells of origin of the corticospinal tract. This beta2 oscillation depends on gap junctional coupling, but it survives a cut through layer 4 and, hence, does not depend on apical dendritic electrogenesis. It also survives a blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors or a blockade of GABA(A) receptors that is sufficient to suppress gamma (30-70 Hz) oscillations in superficial cortical layers. The oscillation period is determined by the M type of K+ current.
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