Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 42, Pages 15675-15680Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0607501103
Keywords
diabetes; obesity
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Funding
- NCI NIH HHS [CA20535, R01 CA020535, R37 CA020535] Funding Source: Medline
- NIDDK NIH HHS [K08 DK073697, R56 DK056084, DK73697, DK07161, T32 DK007161, DK56084, R01 DK056084] Funding Source: Medline
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A pluripotent cell line, C3H10T1/2, is induced to undergo adipogenesis by a mixture of factors that includes a glucocorticoid such as dexamethasone. We found that expression of myostatin (MSTN), a TGF-beta family member extensively studied in muscle, was induced by dexamethasone under those differentiation conditions. Moreover, MSTN could substitute for dexamethasone in the adipogenesis mixture. However, the adipocytes induced by MSTN in both cell culture and transgenic mice were small and expressed markers characteristic of immature adipocytes. These adipocytes exhibited cell-autonomous increases in insulin sensitivity and glucose oxidation. In mice, these effects produced elevated systemic insulin sensitivity and resistance to diet-induced obesity. Modulation of the final stages of adipogenesis may provide a novel approach to understanding and treating metabolic disease.
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