Nanoscale ZnO-enhanced fluorescence detection of protein interactions

Enhanced fluorescence emission is detected from interacting protein pairs of dichlorotriazinylaminofluoresceinstreptavidin and biotinylated bovine serum albumin (see figure) that are adsorbed onto periodically spaced, square-patterned ZnO nanostructures. This florescence-enhancement capability of nanoscale ZnO and its potential easy integration into biosensor arrays may allow ultrasensitive protein detection, which is needed in the areas of biomedical research and in large-scale testing and screening.