Journal
BRAIN RESEARCH
Volume 1115, Issue -, Pages 54-64Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.07.091
Keywords
sodium appetite; salt appetite; fluid ingestion; ingestive behavior; nucleus of the solitary tract; nucleus tractus solitarius; 11HSD2; 11-beta-hydroxysteroid dehydrogenase; type 2; deoxycorticosterone; DOCA
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Funding
- NHLBI NIH HHS [HL-25449] Funding Source: Medline
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The nucleus of the solitary tract (NTS) contains a unique subpopulation of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2). These neurons are mineralocorticoid-sensitive and are activated in association with salt appetite during sodium deficiency. In the absence of sodium deficiency, the HSD2 neurons and sodium appetite are both stimulated by chronic mineralocorticoid administration. After 7 days of treatment with deoxycorticosterone (2 mg/day), an increased number of HSD2 neurons became immunoreactive for the neuronal activity marker c-Fos. When given access to concentrated saline (3% NaCl), deoxycorticosterone-treated rats drank eight times more than vehicle-treated rats. Saline ingestion increased neuronal activation within the medial subdivision of the NTS, but the number of c-Fos-immunoreactive HSD2 neurons was reduced. This finding suggests that the HSD2 neurons are inhibited by signals directly related to saline ingestion, and not simply by the alleviation of sodium deficiency, which does not occur during mineralocorticoid administration. (c) 2006 Published by Elsevier B.V.
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