Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 21, Pages 6162-6165Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm0607810
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Funding
- Wellcome Trust [069719] Funding Source: Medline
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A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding to acetate via a bidentate chelation that can be related to the proposed interaction with aspartate on the receptor protein surface. The zinc(II) complex is highly active against HIV infection in vitro.
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