Journal
SCIENCE
Volume 314, Issue 5798, Pages 475-478Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1129837
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Funding
- NHLBI NIH HHS [U01-HL086528-01] Funding Source: Medline
- NIA NIH HHS [P30AG19610] Funding Source: Medline
- NIMH NIH HHS [R01MH057899] Funding Source: Medline
- NINDS NIH HHS [U24NS051872] Funding Source: Medline
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Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
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