Journal
CELL
Volume 127, Issue 2, Pages 265-275Publisher
CELL PRESS
DOI: 10.1016/j.cell.2006.10.003
Keywords
-
Categories
Ask authors/readers for more resources
Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus-p15(INK4b), p(16INK4a), and ARF-play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p(16INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p(16INK4a), ARF, and p(15INK4b) in cancer and aging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available