Journal
NEUROLOGY
Volume 67, Issue 8, Pages 1506-1508Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000240220.33950.0c
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Funding
- NIA NIH HHS [P01 AG17216] Funding Source: Medline
- NIEHS NIH HHS [R01 ES013941] Funding Source: Medline
- NINDS NIH HHS [P50 NS40256] Funding Source: Medline
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Lrrk2 G2019S is predominantly associated with alpha-synuclein-immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus alpha-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or alpha-synuclein protein with Lrrk2.
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