Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 43, Pages 11208-11219Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3526-06.2006
Keywords
beta 1 integrin; cell adhesion molecule; hippocampus; synaptic maturation; synaptic vesicle pool; long-term potentiation
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Funding
- Intramural NIH HHS Funding Source: Medline
- NINDS NIH HHS [R01NS19090, R01 NS019090-26, R01 NS019090] Funding Source: Medline
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Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions. To study their roles at central synapses, we used two cre recombinase lines to delete the Itgb1 beta 1 integrin gene in forebrain excitatory neurons at different developmental stages. Removal of the beta 1 integrins at an embryonic stage resulted in severe cortical lamination defects without affecting the cellular organization of pyramidal neurons in the CA3 and CA1 regions of the hippocampus. Whereas the hippocampal neurons underwent normal dendritic and synaptic differentiation, the adult synapses exhibited deficits in responses to high-frequency stimulation (HFS), as well as in long-term potentiation (LTP). Deletion of beta 1 integrin at a later postnatal stage also impaired LTP but not synaptic responses to HFS. Thus, the beta 1-class integrins appear to play distinct roles at different stages of synaptic development, critical for the proper maturation of readily releasable pool of vesicles during early development but essential for LTP throughout adult life.
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