4.8 Article

Improving foldamer synthesis through protecting group induced unfolding of aromatic oligoamides

Journal

ORGANIC LETTERS
Volume 8, Issue 22, Pages 5117-5120

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol062103d

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The hydrogen bond rigidified backbones of aromatic oligoamides are temporarily interrupted by replacing the amide hydrogens with the acid-labile 2,4-dimethoxybenzyl (DMB) group, which allows the efficient preparation of long folding oligomers that, upon removal of the DMB groups, fold into multiturn helices.

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